About clozapinedibenzodiazepine derivative , atypical antipsychotic, tranquilizer, anti-psychotic.mechanism of action of clozapineclozapine binds to dopamine receptors. it has more affinity towards d4 receptor than other dopamine receptors i.e.d1, d2, d3 &d5 receptors. it exerts its antipsychotic activity by blocking the dopamine projections in the limbic system. it acts as a competitive dopamine antagonist. clozapine also produces alpha adrenergic blocking activity, anti-serotonin activity and anticholinergic activity. it also produces moderately potent anticholinergic but paradoxically induce salivation and h1 blocking activity.interactions for clozapineanticholinergics: anticholinergic effects may be potentiated. antihypertensives: hypotensive effects may be potentiated. cns drugs: caution is advised with concomitant use. agents that suppress bone marrow function: avoid concomitant use.
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