About diclofenac potassiumnsaid, anti-inflammatory ,antipyretic and analgesic.mechanism of action of diclofenac potassiumdiclofenac possess analgesic, anti-inflammatory and antipyretic action. it inhibits the enzyme cyclo-oxygenase and there by inhibits the synthesis of prostaglandins (((pgs))). it is more potent against cyclo-oxygenase-2 enzyme as compared to other nsaids like indomethacin, naproxen etc. it reduces intracellular concentrations of free arachidonic acid in leukocyte by altering its release or uptake.pharmacokinets of diclofenac potassiumabsorption: diclofenac potassium is rapidly absorbed after oral administration. it undergoes first pass metabolism. distribution: it is distributed in highly protein bound form. metabolism: diclofenac potassium is metabolised in the liver to mainly 4 hydroxy diclofenac. excretion: drug and metabolites are primarily excreted in urine and some amount in the bile.
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