About naltrexonean opioid receptor(competitive antagonists at ?- and ?- receptor) antagonist, in alcohol dependence and opioid dependence.mechanism of action of naltrexonenaltrexone is a competitive opioid antagonist. it reversibly and completely blocks all the opioid receptors (mu, kappa and delta). it is an orally administered long acting, pure opioid antagonist alcoholism: opioid receptors are thought to be responsible for some of the reinforcing effects of alcohol. indications for naltrexone1. opioid antagonist 2. alcoholisminteractions for naltrexonedisulfiram: the safety and efficacy of concomitant use of naltrexone and disulfiram has not been established. concomitant use of two potentially hepatotoxic drugs is ordinarily not recommended. thioridazine: lethargy and somnolence have been reported when naltrexone and thioridazine have been used. others: patients taking naltrexone may not benefit from opioid containing medicines like cough and cold preparations,
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