Amoxicillin is an analog of ampicillin, derived from the basic penicillin nucleus, 6-aminopenicillanic acidclavulanic acid is produced by the fermentation of streptomyces clavuligerus. it is a beta-lactam structurally related to the penicillins and possesses the ability to inactivate some beta-lactamases by blocking the active sites of these enzymes.lower respiratory tract infections - caused by beta-lactamase-producing isolates of haemophilus influenzae and moraxella catarrhalis.acute bacterial otitis media - caused by beta-lactamase-producing isolates of h. influenzae and m. catarrhalis.sinusitis - caused by beta-lactamase-producing isolates of h. influenzae and m. catarrhalis.skin and skin structure infections - caused by beta-lactamase-producing isolates of staphylococcus aureus, escherichia coli, and klebsiella species.urinary tract infections - caused by beta-lactamase-producing isolates of e. coli, klebsiella species, and enterobacter species.
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