About cefiximethird generation cephalosporin oral antibioticmechanism of action of cefiximecefixime is an orally active 3rd generation cephalosporin which exerts its bactericidal action against both gram positive & gram negative organisms by inhibiting bacterial cell wall synthesis. cefixime inhibits transpeptidase & thus prevents cross linking of bacterial cell wall. transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporins like cefixime. it is highly active against enterobacteriaceae, haemophilus influenzae, streptococcus pyogens & streptococcus pneumonia &many beta lactamase producing bacteria.indications for cefixime1.tonsillitis 2.pharyngitis 3.otitismedia 4.bronchitis 5.urinary tract infections 6.gonorrhea 7.infections caused by susceptible organisms.
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