About aripiprazolesecond-generation atypical antipsychotic, dopamine-serotonin stabilizer. mechanism of action of aripiprazolethe mechanism of action of aripiprazole in the treatment of schizophrenia and bipolar disorder is unknown. the proposed mechanism is that aripiprazole acts by combination of partial agonist activity at dopamine (d2) and serotonin (5ht1a) receptor and a potent antagonist at 5ht2a receptor. aripiprazole also has an antagonist activity at alpha1 adrenergic receptors. indications for aripiprazole1.schizophrenia 2.bipolar disorder interactions for aripiprazolecarbamazepine: it cause an increase in aripiprazole clearance and lower blood levels ketoconazole, quinidine, fluoxetine, paroxetine: they inhibt aripirazole elimination and cause increased blood levels.
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