Leuprorelin (leuprolide acetate) is a gonadotrophin-releasing hormone (gnrh) analogue used to treat a wide range of sex hormone-related disorders including advanced prostatic cancer, endometriosis and precocious puberty. it acts primarily on the anterior pituitary, inducing a transient early rise in gonadotrophin release. with continued use, leuprorelin causes pituitary desensitisation and/or down-regulation, leading to suppressed circulating levels of gonadotrophins and sex hormones.
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