About cefotaximethird generation cephalosporin parenteral antibiotic.mechanism of action of cefotaximecefotaxime is a 3rd generation cephalosporin which exerts its bactericidal action against both gram positive & aerobic gram negative organisms by inhibiting bacterial cell wall synthesis. cefotaxime inhibits transpeptidase & thus prevents cross linking of bacterial cell wall. transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporins like cefotaximeindications for cefotaxime1.meningitis 2.resistant hospital acquired infections 3.septicemia 4.infections in immunocompromised patients 5.urinary tract &genital tract infections 6.surgical prophylaxis 7.skin & soft tissue infections 8.bone & joint infections 9.gonorrhea. interactions for cefotaximesynergy with aminoglycosides.
المزيد من التفاصيل