About nalbuphinesynthetic opiate agonist/antagonist, narcotic analgesicsmechanism of action of nalbuphinenalbuphine is a phenanthrene derivative opioid analgesic with mixed opioid agonist and antagonist activity. it inhibits the ascending pain pathways, altering the perception of and response to pain by binding to opiate receptors in the cns. nalbuphine is thought primarily to be a kappa agonist. it is also a partial mu antagonist analgesic, with some binding to the delta receptor and minimal agonist activity at the sigma receptorindications for nalbuphine1.moderate to severe pain 2.as an adjunct in balanced anesthesia interactions for nalbuphineadditive cns depressant effects may occur with other cns depressants e.g. alcohol, anaesthetics, anxiolytics, hypnotics, tcas and antipsychotics
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