About fluphenazinefirst-generation antipsychotic, phenothiazine:piperazine derivative, typical antipsychotic.mechanism of action of fluphenazinefluphenazine binds to the dopamine receptor (d1, d2, d3 &d4).it exerts its antipsychotic activity by blocking the dopamine projections in the limbic system and in mesocortical area. peripherally and centrally it acts as a competitive dopamine antagonist. fluphenazine also produces alpha adrenergic blocking activity and anticholinergic activity. it also produces weak h1 antihistaminic activity and anti serotonin activity
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