About losartan potassiumsan angiotensin ii receptor antagonist, antihypertensive.ssmechanism of action of losartan potassiumsit is a competitive antagonist of angiotensin-2 at at-1 receptor. it decreases peripheral resistance and lowers bp in hypertensive individuals. it blocks all overt actions of angiotensin-2 such as: - 1. vasoconstriction, 2. central & peripheral sympathetic stimulus, 3. release of aldosterone and adrenaline, 4. salt and water reabsorption, 5. central actions like thirst, vasopressin release, and growth promoting actions on heart and blood vessels.ssinteractions for losartan potassiumsdiuretics, other antihypertensives: potentiate the hypotensive effect of losartan. spotassium sparing diuretics, potassium suppliments: risk of hyperkalaemia. snsaids: may blunt hypotensive effect of losartan. scytochrome p450 inhibitors like ketoconazole: increase in auc of losartan by 18 % but has no effect on its active metabolite. s
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