About cetirizinessecond generation h1 antagonist, metabolite of hydroxyzine, antihistamine.ssmechanism of action of cetirizinesthis drug is a selective peripheral h1 receptor antagonist. thus it inhibits the allergic symptoms produced by histamines like cold, rhinorrhea, sneezing, urticaria etc. the drug has some mast cell stabilizing properties. it also inhibit eotaxin-induced eosinophil tem through both dermal and lung micro vascular endothelial cells. so inhibit eosinophil chemotaxis and also inflammation caused by it.ssindications for cetirizines1. sneezing s2. rhinorrhoea s3. postnasal discharge. s4. common coughs s5. colds. s6. chronic urticaria s7. dermatitis s8. pruritic skin disorders s9. hay fever s10. angioedema
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